NMN is an entirely natural compound found in our bodies. Various food sources also contain this compound in minuscule amounts. Edamame which has one of the higher contents, only show less than 1.9mg/100g. NMN is a direct and potent NAD+ supplement. Mice given an oral supplement of NMN showed increased liver NAD+ levels in just 10 minutes and showed an increase in muscle tissue by 30 minutes.

Increased NAD+ levels stimulate energy metabolism, DNA repair, and SIRTUIN activity. SIRTUINS are the longevity-genes shown to be active during caloric restriction and life-extension in many animal models.

THE SCIENCE

Scientists have now confirmed a direct link between falling NAD+ levels and aging in both animals and human subjects. A breakthrough study published by Harvard scientists in 2013 showed for the first time that some aspects of aging might be reversible. After treating old mice with NMN, several biometric markers that were subsequently measured resembled those of young mice: "the equivalent of a 60-year old converting to a 20-year old". The research and understanding into NAD+ metabolomics are ongoing, but what the science has highlighted thus far, is the importance of supporting and maintaining our NAD+ levels.

A long-term evaluation of oral supplementation of NMN in mice was found to be effective at improving NAD+ levels safely. Mice supplemented with NMN vs. a control group showed notable age-associated differences in mass, energy metabolism, blood sugar, lipid metabolism, gene expression changes, mitochondrial oxygen use, eye function, bone density and immune function with no apparent toxic effects.

How to Use

Take 1 capsule daily or as recommended by your health professional.

We use stabilized NMN that will not degrade at room temperature.

Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism, and gene expression in the body. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient. In fact, NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, brain health, heart health, body weight, and gene expression.

Our patented delayed release, acid resistant capsules protect NMN from stomach acid. These innovative capsules are designed to release their contents in the small intestine, where it can be most readily absorbed by the body.

What are the benefits associated to Nicotinamide Monocleotide?

At a conference on the biology of ageing organised by the Ellison Medical Foundation, Dr Shin-Ichiro Imai demonstrated that sirtuins are necessary for calorie restriction to be able to improve the activity of orexin, a brain hormone which enhances cells' sensitivity to insulin and prevents increases in body fat.

However, sirtuins alone are not enough - cellular NAD+ must also be present for these beneficial processes to work. The problem is, levels of NAD+ decline both with age and as a result of a high-fat diet. The good news, according to Dr Imai, is that in NMN-treated mice, researchers observed an increase in NAD+ synthesis, suggesting NMN could be a potential treatment for type 2 diabetes.

• NMN not only helps prolong life expectancy but has also shown promise in treating type 2 diabetes.

• This degenerative disease is directly linked to over-consumption of fat and calories which overwhelm adaptive metabolic pathways.

• Mouse studies showed that NMN improved glucose tolerance by restoring NAD+ levels.

• It enhanced insulin sensitivity in the liver, restored impaired gene expression related to oxidative stress, inflammatory response and the circadian rhythm by activating SIRT1.

What is NAD+

Found in all living cells, NAD+ is a coenzyme involved in redox reactions. It consists of two nucleotides linked by their phosphate group. One nucleotide contains an adenine, the other a nicotinamide. It helps enzymes transfer electrons during redox reactions to form ATP and is thus an aid to energy supply.

However, levels decline with age - the NAD+ in an older person's cells will have fallen by more than 50%. The mitochondria then produce less energy and cells age. Fortunately, this process is not irreversible and intercellular energy mechanisms can be restored if levels of NAD+ are increased.

In addition, NAD is an essential cofactor of key longevity enzymes called sirtuins, activating them directly. Sirtuins play a fundamental role in life expectancy as they deactivate particular genes that lead to ageing via inflammatory processes. Thus the combined fall in sirtuins 1 and 3, and in NAD+, can cause cerebral degeneration, vascular inflammation, fatigue, loss of muscle strength, increased fat stores around the liver and abdomen and insulin resistance leading directly to metabolic syndrome. All of these processes can be reversed by means of calorie restriction or supplementation with nicotinamide mononucleotide.

What do studies show about Nicotinamide Mononucleotide?

• An experiment on NMN in mice conducted by Professor David Sinclair of Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat ageing and its associated diseases (cancer and type 2 diabetes).

• When Professor Sinclair and his colleagues injected this rare substance into two-year-old mice, they observed, after just one week's treatment, notable improvements to muscle (a reduction in muscle atrophy), enhanced insulin resistance and reduced inflammation, making the mice indistinguishable from younger animals.

• According to Dr Nigel Turner, a pharmacologist at the University of New South Wales, “It's like a 60-year-old being similar to a 20-year-old on some measures”. Professor Sinclair added: “If these results stand, then ageing may be a reversible condition, if it is caught early".

• In a report published in the journal Cell, the researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale - less than a week, in fact.

• The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN's ability to activate all seven of the SIRT genes involved in extending longevity.

• He believes nicotinamide mononucleotide could be a new class of super drug capable of both preventing diseases such as cancer (via inhibition of HIF-1, a molecule that impairs intracellular communication and plays a role in cancer development) and Parkinson's disease, and extending life expectancy to 150 years.

• In humans as in mice, nicotinamide mononucleotide, at an average daily dose of 125mg - 1 capsule a day - could produce a natural reversal of the ageing process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.

Why is it important to supplement with Nicotinamide Mononucleotide?

The mitochondria are at the heart of the problem. When they stop communicating properly with the cell nucleus, it is almost as if the cells are deprived of their energy source or battery - their nuclei shrink and ageing becomes inevitable. For Professor David Sinclair, “The ageing process can be compared to a married couple - when they're young, they communicate well, but over time, that communication breaks down. And just as with a married couple, restoring communication solved the problem”.

This scientist therefore sees the decline in mitochondrial function and communication as a reversible process. He explains that NAD+ is the central pillar of cell communication but that it decreases sharply with age - until now, the only known way of preventing this loss has been through intensive exercise or calorie restriction.

In addition to this innovative formulation, you may also be interested in other anti-ageing supplements available to buy at Supersmart, that offer effective and long-lasting protection from the effects of ageing. The potent AMPK Booster, for example, is formulated to reactivate AMPK, a key enzyme of metabolism, levels of which decline with age. The complex Natural Rapalogs contains five natural inhibitors of mTOR proteins, inhibition of which may combat premature ageing. You can also benefit from the optimised formulation Longevity Nutrients which combines a selection of natural anti-ageing nutrients.

Buy Nicotinamide Mononucleotide capsules to naturally fight the ageing process.